Medical Books, Medical Textbook Online

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Studies in the Metabolism of Vitamin B12 was first published in 1965. Dr. Doscherholmen has conducted extensive studies of the physiological aspects of vitamin B12 metabolism in man, and in this book he describes the investigations, reports the findings, and reviews the literature. He also reports on laboratory animal studies which contribute to a knowledge of the subject. The major investigations were performed in a clinical setting and involved the administration of doses of radiocyanocobalamin, the radioactive form of vitamin B12, to patients offlicted with various diseases and to normal subjects. In order to diagnose malabsorption of B12, the Schilling test was performed on patients having pernicious anemia, partial or total gastrectomy, histamine-fasct achlorhydria, posterolateral column disease without anemia, intestinal megaloblastic anemia, regional ileitis, sprue, secondary steatorrhea, cirrhosis of the liver, leukemia, and various types of neuritis. The author assesses the most commonly used methods of testing B12 absorption, the urinary excretion test, and reports his attempts to improve the urinary recovery of radioactivity. He describes a new technique for the measurement of B12 absorption — the plasma absorption test — and evaluates its clinical usefulness. He also reports on studies of the basic mechanism of the Schilling test, the organ distribution of radioactivity, and the kinetics of cyanocobalamin in man after the oral ingestion of physiologic doses of radiocyanocobalamin. Additional studies described are concerned with the B12 binding power of serum as determined through an ultrafiltration technique, the enzymatic release of B12 in the small intestine of rats, and the hepatic storage of radiocyanocobalamin. There is an extensive bibliography.

Studies in the Metabolism of Vitamin B12

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Text provides a summary of current knowledge on homocysteine as a marker of B-vitamin deficiency, and as a potential causal risk factor of cardiovascular disease, birth defects, and CNS-dysfunction. Aims to give an overview of psychological and pathophysiological aspects of the homocysteine metabolism. Color figures. Previous edition: c1999. Softcover.

Focus on Homocysteine and the Vitamins Involved in Its Metabolism

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Clinical Gynecologic Endocrinology and Infertility

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This volume considers the spectrum of factors that influence the generation of ATP for exercise and sport. For students and researchers in exercise physiology. Covers chemomechanical coupling in muscle, substrate supply & energy metabolism, hydrogen Ions, electrolyte imbalance, endogenous substrate supply, mitochronddrial utilization of oxygen, adrenergic regulation, pancreatic and gut hormones, diet.

Perspectives in Exercise Science and Sports Medicine: Energy Metabolism in Exercise and Sport

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Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology

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In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volume’s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

Genomics in Endocrinology: DNA Microarray Analysis in Endocrine Health and Disease

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McGill Univ., Montreal, Quebec, Canada. Text is a compilation of key topics covered at annual meetings and reflects the latest thinking on the subject. Analyzes various reproductive and gynecological disorders of those who do not wish to conceive, as well as those who have difficulty with conception, early pregnancy, and menopause. For clinicians and researchers.

Reproductive Endocrinology and Infertility: Current Trends and Developments

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Univ. of Utah, Salt Lake City. Text aims to assist the endocrinologist in the management of patients with hormonal deficiencies or altered hormonal synthesis. Includes guidelines for the management of diabetes and discusses androgen, estrogen, thyroid hormone, and water metabolism. Also addresses male and female fertility issues.

Endocrine Replacement Therapy in Clinical Practice

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Amenorrhea: A Case-Based Clinical Guide is a comprehensive review of the current knowledge regarding normal female reproductive physiology. Replete with interesting case vignettes and providing diagnostic algorithms and therapeutic strategies for amenorrhea, Amenorrhea: A Case-Based Clinical Guide is divided into three sections. The first section is composed of two chapters that provide a thorough review of basic science and clinical knowledge about the organ systems responsible for normal physiology of the menstrual cycle. The second section includes discussion about menstrual cycle disruption as it relates to hypothalamic-pituitary dysfunction, surgical and natural menopause, genetic defects, premature ovarian failure/insufficiency and the effects of caloric excess and restriction. The third section offers an update on the physiological effects of prolonged amenorrhea induced surgically or by hypothalamic dysfunction and also includes an original chapter that focuses solely on the impact of race and ethnicity on the prevalence and diagnosis of amenorrhea. Amenorrhea: A Case-Based Clinical Guide brings together chapters from renowned experts who offer state-of-the-art, clinically useful information in a case-based, reader-friendly fashion. This title will be a welcome addition to the bookshelves of all clinicians who practice in women’s health settings.

Amenorrhea: A Case-Based, Clinical Guide

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Cancer cachexia is a complex syndrome characterized by diminished nutrient intake and progressive tissue depletion manifest clinically as anorexia and weight loss. This review examines the basic research that has addressed the fundamental derangements in host intermediary protein metabolism and evaluates current therapeutic approaches to the management of cancer cachexia. This volume provides a new approach as well as a comprehensive review of current basic and clinical research.

Protein and Amino Acid Metabolism in Cancer Cachexia